Blood pressure and cerebral oxygenation with physiologically-based cord clamping: sub-study of the BabyDUCC trial

S Badurdeen; DA Blank; M Hoq; FY Wong; CT Roberts; SB Hooper; GR Polglase; PG Davis

Journal article

Blood pressure and cerebral oxygenation with physiologically-based cord clamping: sub-study of the BabyDUCC trial

S Badurdeen, DA Blank, M Hoq, FY Wong, CT Roberts, SB Hooper, GR Polglase, PG Davis

Pediatric Research | SPRINGERNATURE | Published : 2024

DOI: 10.1038/s41390-024-03131-5

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Abstract

Background: Cord-clamping strategies may modify blood pressure (BP) and cerebral tissue oxygen saturation (rStO2) immediately after birth. Methods: We conducted a sub-study nested within the Baby-Directed Umbilical Cord-Clamping trial. Infants ≥32+0 weeks’ gestation assessed as requiring resuscitation were randomly allocated to either physiologically-based cord clamping (PBCC), where resuscitation commenced prior to umbilical cord clamping, or standard care where cord clamping occurred early (ECC). In this single-site sub-study, we obtained additional measurements of pre-ductal BP and rStO2. In a separate observational arm, non-randomised vigorous infants received 2 min of deferred cord clam..

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University of Melbourne Researchers

Shiraz Badurdeen Author

Peter Davis Author

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) through the Centre for Research Excellence in Newborn Medicine (GNT1153176), Programme Grant (#606789) and Fellowships (S.B.H.: APP545921, G.R.P.:APP1105526, P.G.D.: APP1059111, C.T.R.: 1175634). S.B. was supported by an Australian Government Research Training Program Scholarship. A Near-Infrared Spectroscopy device was provided on loan by Nonin. The funders had no role in thein the study design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication. Open Access funding enabled and organized by CAUL and its Member Institutions.